Mesquite seasoning is a popular spice blend that is commonly used in Southwestern cuisine. The history of mesquite seasoning can be traced back to the indigenous tribes of the Southwestern United States and Mexico.

Native Americans, such as the Apache, Navajo, and Pueblo, used mesquite as a food source for centuries. They would grind the mesquite pods into a flour that could be used for baking, and also used the wood to smoke meat and fish.

The flavor of mesquite became popular in the United States during the 20th century, when it was discovered that mesquite wood could be used to smoke meat. The smoky, sweet flavor of mesquite became a staple of Southwestern cuisine, and the seasoning blend soon followed.

Today, mesquite seasoning typically includes a blend of spices such as paprika, chili powder, garlic, onion, cumin, and of course, mesquite powder. It is often used to season meats such as beef, chicken, and pork, and can also be used to add flavor to vegetables, beans, and grains.